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The previous major release was an almost complete rewrite of the software, along with new features focused on multi-modality image support. It was funded in part by a grant from the Chan-Zuckerberg Initiative. ITK-SNAP 4.0 is the first major release since 2020, and focuses on improved 3D+time image support. The design also emphasizes interaction and ease of use, with the bulk of the development effort dedicated to the user interface. True to its original vision, ITK-SNAP design focuses specifically on the problem of image segmentation, and extraneous or unrelated features are kept to a minimum.

Extensive tutorial and video documentation.

Access to advanced algorithms through the distributed segmentation service (DSS).

3D cut-plane tool for fast post-processing of segmentation results.

Between-slice segmentation interpolation.

Manual and automatic image registration capabilities.

Support for color, multi-channel, and 3D+time images.

Support for concurrent, linked viewing, and segmentation of multiple images.

Support for many different 3D image formats, including NIfTI and DICOM.

A modern graphical user interface based on Qt6.

Manual segmentation in three orthogonal planes at once Git comes with built-in GUI tools (git-gui, gitk), but there are several third-party tools for users looking for a platform-specific experience.Linked cursor for seamless 3D navigation.